C/EBP homologous protein (CHOP) up-regulates IL-6 transcription by trapping negative regulating NF-IL6 isoform

被引：51

作者：

Hattori, T ^{[1
]}

Ohoka, N ^{[1
]}

Hayashi, H ^{[1
]}

Onozaki, K ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Dept Mol Hlth Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

FEBS LETTERS | 2003年 / 541卷 / 1-3期

基金：

日本学术振兴会;

关键词：

C/EBP homologous protein; nuclear factor for IL-6 expression; liver-enriched inhibitory protein; interleukin-6; transcription; dimer;

D O I：

10.1016/S0014-5793(03)00283-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin-6 (IL-6) production is up-regulated by several stimuli through the activation of transcription factors. We have previously demonstrated that CCAAT/enhancer binding protein homologous protein (CHOP) positively regulates IL-6 production at the transcriptional level in the human melanoma cell line A375. In this study, we provide evidence that CHOP up-regulates the IL-6 transcription without binding to the IL-6 promoter. CHOP dimerized more preferentially with an inhibitory isoform of nuclear factor for IL-6 expression (LIP (liver-enriched inhibitory protein)) than with a positively acting isoform (LAP, liver-enriched activator protein). These results indicate that CHOP plays an important role in IL-6 production without binding to its promoter, probably by trapping protein(s) such as LIP, which would otherwise inhibit IL-6 transcription. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：33 / 39

页数：7

共 29 条

[1] INTERLEUKIN-6 IN BIOLOGY AND MEDICINE [J].