The αβ versus γδ T-cell lineage choice

被引:48
作者
Robey, E
Fowlkes, BJ
机构
[1] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA
[2] NIAID, LCMI, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1016/S0952-7915(98)80247-1
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
During thymic development, immature T cells rearrange and express the genes encoding the T-cell antigen receptor and mature as either alpha beta or gamma delta lineage T cells. In the past year, advances have been made in understanding the role of individual components of the T-cell antigen receptor complex in the development of alpha beta and gamma delta lineage T cells. In addition, the transmembrane receptor Notch has recently been implicated as a new player in alpha beta versus gamma delta lineage determination. (C) Current Biology Ltd ISSN 0952-7915.
引用
收藏
页码:181 / 187
页数:7
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