Therapeutic potential for microRNAs

被引：148

作者：

Esau, Christine C. ^{[1
]}

Monia, Brett P. ^{[1
]}

机构：

[1] ISIS Pharmaceut, Carlsbad, CA 92008 USA

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2007年 / 59卷 / 2-3期

关键词：

microRNA; antisense oligonucleotides; siRNA;

D O I：

10.1016/j.addr.2007.03.007

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

MiRNAs are a conserved class of non-coding RNAs that negatively regulate gene expression post-transcriptionally. Although their biological roles are largely unknown, examples of their importance in cancer, metabolic disease, and viral infection are accumulating, suggesting that they represent a new class of drug targets in these and likely many other therapeutic areas. Antisense oligonucleotide approaches for inhibiting miRNA function and siRNA-like technologies for replacement of miRNAs are currently being explored as tools for uncovering miRNA biology and as potential therapeutic agents. The next few years should see significant progress in our understanding of miRNA biology and the advancement of the technology for therapeutic modulation of miRNA activity. (C) 2007 Elsevier B.V. All rights reserved.

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收藏

页码：101 / 114

页数：14

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