Banff '09 Meeting Report: Antibody Mediated Graft Deterioration and Implementation of Banff Working Groups

被引：606

作者：

Sis, B. ^{[1
,2
]}

Mengel, M. ^{[1
,2
]}

Haas, M. ^{[3
]}

Colvin, R. B. ^{[4
,5
]}

Halloran, P. F. ^{[2
]}

Racusen, L. C. ^{[6
]}

Solez, K. ^{[1
]}

Baldwin, W. M., III ^{[7
]}

Bracamonte, E. R. ^{[8
]}

Broecker, V. ^{[9
]}

Cosio, F. ^{[10
]}

Demetris, A. J. ^{[11
]}

Drachenberg, C. ^{[12
]}

Einecke, G. ^{[13
]}

Gloor, J. ^{[10
]}

Glotz, D. ^{[14
]}

Kraus, E. ^{[15
]}

Legendre, C. ^{[16
,17
]}

Liapis, H. ^{[18
]}

Mannon, R. B. ^{[19
]}

Nankivell, B. J. ^{[20
]}

Nickeleit, V. ^{[21
]}

Papadimitriou, J. C. ^{[12
]}

Randhawa, P. ^{[11
]}

Regele, H. ^{[22
]}

Renaudin, K. ^{[23
]}

Rodriguez, E. R. ^{[24
]}

Seron, D. ^{[25
]}

Seshan, S. ^{[26
]}

Suthanthiran, M. ^{[27
]}

Wasowska, B. A. ^{[6
]}

Zachary, A. ^{[15
]}

Zeevi, A. ^{[11
]}

机构：

[1] Univ Alberta, Dept Lab Med & Pathol, Edmonton, AB, Canada

[2] Univ Alberta, Dept Med, Div Nephrol & Immunol, Alberta Transplant Appl Genom Ctr, Edmonton, AB, Canada

[3] Cedars Sinai Med Ctr, Dept Pathol & Lab Med, Los Angeles, CA 90048 USA

[4] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

[5] Massachusetts Gen Hosp, Boston, MA 02114 USA

[6] Johns Hopkins Univ, Dept Pathol, Baltimore, MD USA

[7] Cleveland Clin, Dept Immunol, Lerner Res Inst, Cleveland, OH 44106 USA

[8] Univ Arizona, Dept Pathol, Tucson, AZ USA

[9] Hannover Med Sch, Dept Pathol, Hannover, Germany

[10] Mayo Fdn & Clin, Div Nephrol & Hypertens, Rochester, NY USA

[11] Univ Pittsburgh, Dept Pathol, Div Transplantat Pathol, Pittsburgh, PA USA

[12] Univ Maryland, Dept Pathol, Baltimore, MD 21201 USA

[13] Hannover Med Sch, Dept Nephrol, Hannover, Germany

[14] Hosp St Louis, Dept Nephrol, Paris, France

[15] Johns Hopkins Univ, Dept Med, Baltimore, MD USA

[16] Hop Necker Enfants Malad, Serv Transplantat, Paris, France

[17] Univ Paris 05, Paris, France

[18] Washington Univ, Dept Pathol & Immunol, Sch Med, St Louis, MO USA

[19] Univ Alabama Birmingham, Div Nephrol, Birmingham, AL USA

[20] Westmead Hosp, Ctr Transplant Res & Renal Res, Sydney, NSW, Australia

[21] Univ N Carolina, Dept Lab Med & Pathol, Chapel Hill, NC USA

[22] Univ Vienna, Inst Pathol, Vienna, Austria

[23] CHU Hotel Dieu, Dept Pathol, Nantes, France

[24] Cleveland Clin, Dept Anat Pathol, Cleveland, OH 44106 USA

[25] Hosp Gen Valle Hebron, Dept Nephrol, Barcelona, Spain

[26] New York Presbyterian Hosp, Weill Cornell Med Coll, Dept Pathol & Lab Med, New York, NY USA

[27] Cornell Univ, Weill Med Coll, Div Nephrol, Dept Med, New York, NY 10021 USA

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2010年 / 10卷 / 03期

关键词：

Acute allograft rejection; acute cellular rejection; acute rejection; allograft rejection; antibody mediated rejection; Banff; Banff lesions; Banff schema; classification; chronic allograft rejection; donor specific antibody; genomic markers; GeneChip; heart allograft; microarrays; proteomics; pancreas allograft; transplantation; DONOR-SPECIFIC ANTIBODIES; HUMAN-LEUKOCYTE ANTIGEN; RENAL-ALLOGRAFT REJECTION; POSITIVE CROSS-MATCH; TRANSPLANT GLOMERULOPATHY; KIDNEY-TRANSPLANTS; C4D DEPOSITION; ACTIVATING ANTIBODIES; PATHOLOGICAL FEATURES; HUMORAL REJECTION;

D O I：

10.1111/j.1600-6143.2009.02987.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

The 10th Banff Conference on Allograft Pathology was held in Banff, Canada from August 9 to 14, 2009. A total of 263 transplant clinicians, pathologists, surgeons, immunologists and researchers discussed several aspects of solid organ transplants with a special focus on antibody mediated graft injury. The willingness of the Banff process to adapt continuously in response to new research and improve potential weaknesses, led to the implementation of six working groups on the following areas: isolated v-lesion, fibrosis scoring, glomerular lesions, molecular pathology, polyomavirus nephropathy and quality assurance. Banff working groups will conduct multicenter trials to evaluate the clinical relevance, practical feasibility and reproducibility of potential changes to the Banff classification. There were also sessions on quality improvement in biopsy reading and utilization of virtual microscopy for maintaining competence in transplant biopsy interpretation. In addition, compelling molecular research data led to the discussion of incorporation of omics-technologies and discovery of new tissue markers with the goal of combining histopathology and molecular parameters within the Banff working classification in the near future.

引用

页码：464 / 471

页数：8

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