Cloning and characterization of human histone deacetylase 8

被引：103

作者：

Van den Wyngaert, I

de Vries, W

Kremer, A

Neefs, JM

Verhasselt, P

Luyten, WHML

Kass, SU

机构：

[1] Janssen Res Fdn, Dept Adv Biotechnol, B-2340 Beerse, Belgium

[2] Janssen Res Fdn, Dept Pharmacogenom, B-2340 Beerse, Belgium

[3] Janssen Res Fdn, Dept Biotechnol, B-2340 Beerse, Belgium

来源：

FEBS LETTERS | 2000年 / 478卷 / 1-2期

关键词：

histone deacetylation; transcriptional regulation; cancer; X chromosome;

D O I：

10.1016/S0014-5793(00)01813-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To date, seven different human histone deacetylases (HDACs) have been identified, which fall into two distinct classes. We have isolated and characterized a cDNA encoding a novel human HDAC, which we name HDAC8, HDAC8 shows a high degree of sequence similarity to HDAC1 and HDAC2 and thus belongs to the class I of HDACs. HDAC8 is expressed in a variety of tissues. Human cells overexpressing HDAC8 localize the protein in sub-nuclear compartments whereas HDAC1 shows an even nuclear distribution. In addition, the HDAC8 gene is localized oil the X chromosome at position q13, which is close to the XIST gene and chromosomal breakpoints associated with preleukemia. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

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页码：77 / 83

页数：7

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