Recent developments in the transcriptional regulation of cytolytic effector cells

被引：243

作者：

Glimcher, LH

Townsend, MJ

Sullivan, BM

Lord, GM

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2004年 / 4卷 / 11期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nri1490

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transcription factors have a profound influence on both the differentiation and effector function of cells of the immune system. T-bet controls the cytotoxicity of CD8(+) T cells and the production of interferon-gamma, and it also affects the development and function of natural killer cells and natural killer T cells. Other factors such as eomesodermin, MEF, ETS1 and members of the interferon-regulatory factor family also contribute to the effector function of immune cells. In this review, we focus on recent studies that have shed light on the transcriptional mechanisms that regulate cellular effector function in the immune system.

引用

收藏

页码：900 / 911

页数：12

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