In vitro antiinflammatory effects of neolignan woorenosides from the rhizomes of Coptis japonica

被引：47

作者：

Cho, JY ^{[1
]}

Baik, KU

Yoo, ES

Yoshikawa, K

Park, MH

机构：

[1] Daewoong Pharmaceut Co Ltd, R&D Ctr, Dept Immunopharmacol, Songnam 462120, South Korea

[2] Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro, Tokushima 770, Japan

[3] UCL, Sch Med, Windeyer Inst Med Sci, Dept Immunol, London W1P 6DB, England

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 09期

关键词：

D O I：

10.1021/np9902791

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five dihydrobenzofuran neolignans, woorenosides I (1), II (2), III (3), IV (4), and V (5), isolated from Coptis japonica (Ranunculaceae), suppressed tumor necrosis factor (TNF)-alpha and nitric oxide (NO) production, as well as lymphocyte proliferation triggered by inflammatory signals such as various mitogens, in a dose-dependent manner. The results indicate that the woorenosides strongly inhibit the mitogenic response by activated macrophage and lymphocytes and suggest that these compounds may participate in regulating inflammatory processes.

引用

页码：1205 / 1209

页数：5

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