Feline immunodeficiency virus (FIV) in wild Pallas' cats

被引：21

作者：

Brown, Meredith A. ^{[1
]}

Munkhtsog, Bariushaa ^{[2
]}

Troyer, Jennifer L. ^{[3
]}

Ross, Steve ^{[4
]}

Sellers, Rani ^{[5
]}

Fine, Amanda E. ^{[6
]}

Swanson, William F. ^{[7
]}

Roelke, Melody E. ^{[3
]}

O'Brien, Stephen J. ^{[1
]}

机构：

[1] NCI, Lab Genom Divers, Frederick, MD 21702 USA

[2] Mongolian Acad Sci, Inst Biol, Ulaanbaatar 51, Bzd, Mongolia

[3] SAIC Frederick Inc, Lab Genom Divers, Frederick, MD 21702 USA

[4] Univ Bristol, Sch Biol Sci, Bristol BS8 1UG, Avon, England

[5] Yeshiva Univ, Albert Einstein Coll Med, Dept Pathol, Bronx, NY USA

[6] Mongolia Country Program, Wildlife Conservat Soc, Ulaanbaatar 211238, Mongolia

[7] Ctr Conservat & Res Endangered Wildlife, Cincinnati, OH 45220 USA

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 2010年 / 134卷 / 1-2期

关键词：

FIV; Pallas' cat; Evolution; Histopathology; Felidae; DIVERGENCE; LIONS; TRANSMISSION; ORGANIZATION; POPULATION; INFECTION; PATTERNS;

D O I：

10.1016/j.vetimm.2009.10.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Feline immunodeficiency virus (FIV), a feline lentivirus related to HIV, causes immune dysfunction in domestic and wild cats. The Pallas' cat is the only species from Asia known to harbor a species-specific strain of FIV designated FIVOma in natural populations. Here, a 25% seroprevalence of FIV is reported from 28 wild Mongolian Pallas' cats sampled from 2000 to 2008. Phylogenetic analysis of proviral RT-Pol from eight FIVOma isolates from Mongolia, Russia, China and Kazakhstan reveals a unique monophyletic lineage of the virus within the Pallas' cat population, most closely related to the African cheetah and leopard FIV strains. Histopathological examination of lymph node and spleen from infected and uninfected Pallas' cats suggests that FIVOma causes immune depletion in its' native host. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：90 / 95

页数：6

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