BIOCHEMISTRY Reengineering Enzymes

被引：18

作者：

Lutz, Stefan ^{[1
]}

机构：

[1] Emory Univ, Dept Chem, Atlanta, GA 30322 USA

来源：

SCIENCE | 2010年 / 329卷 / 5989期

关键词：

DIELS-ALDER REACTION; CATALYSIS; DESIGN;

D O I：

10.1126/science.1192224

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

First-principles design and directed evolution expand the role of enzymes in chemical synthesis.

引用

页码：285 / 287

页数：3

共 17 条

[1] Lovastatin nonaketide synthase catalyzes an intramolecular Diels-Alder reaction of a substrate analogue [J].

Auclair, K ;

Sutherland, A ;

Kennedy, J ;

Witter, DJ ;

Van den Heever, JP ;

Hutchinson, CR ;

Vederas, JC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (46) :11519-11520

[2] Relating protein motion to catalysis [J].

Hammes-Schiffer, Sharon ;

Benkovic, Stephen J. .

ANNUAL REVIEW OF BIOCHEMISTRY, 2006, 75 :519-541

[3] Intrinsic motions along an enzymatic reaction trajectory [J].

Henzler-Wildman, Katherine A. ;

Thai, Vu ;

Lei, Ming ;

Ott, Maria ;

Wolf-Watz, Magnus ;

Fenn, Tim ;

Pozharski, Ed ;

Wilson, Mark A. ;

Petsko, Gregory A. ;

Karplus, Martin ;

Huebner, Christian G. ;

Kern, Dorothee .

NATURE, 2007, 450 (7171) :838-U13

[4] ANTIBODY CATALYSIS OF A DIELS-ALDER REACTION [J].

HILVERT, D ;

HILL, KW ;

NARED, KD ;

AUDITOR, MTM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1989, 111 (26) :9261-9262

[5] De novo computational design of retro-aldol enzymes [J].

Jiang, Lin ;

Althoff, Eric A. ;

Clemente, Fernando R. ;

Doyle, Lindsey ;

Rothlisberger, Daniela ;

Zanghellini, Alexandre ;

Gallaher, Jasmine L. ;

Betker, Jamie L. ;

Tanaka, Fujie ;

Barbas, Carlos F., III ;

Hilvert, Donald ;

Houk, Kendall N. ;

Stoddard, Barry L. ;

Baker, David .

SCIENCE, 2008, 319 (5868) :1387-1391

[6] Finding better protein engineering strategies [J].

Kazlauskas, Romas J. ;

Bornscheuer, Uwe T. .

NATURE CHEMICAL BIOLOGY, 2009, 5 (08) :526-529

[7] Asymmetric Synthesis of Optically Pure Pharmacologically Relevant Amines Employing ω-Transaminases [J].

Koszelewski, Dominik ;

Lavandera, Ivan ;

Clay, Dorina ;

Rozzell, David ;

Kroutil, Wolfgang .

ADVANCED SYNTHESIS & CATALYSIS, 2008, 350 (17) :2761-2766

[8]

Nicolaou KC, 2002, ANGEW CHEM INT EDIT, V41, P1668, DOI 10.1002/1521-3773(20020517)41:10<1668::AID-ANIE1668>3.0.CO

[9]

2-Z

[10] ENZYMATIC-ACTIVITY CATALYZING EXO-SELECTIVE DIELS-ALDER REACTION IN SOLANAPYRONE BIOSYNTHESIS [J].

OIKAWA, H ;

KATAYAMA, K ;

SUZUKI, Y ;

ICHIHARA, A .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (13) :1321-1322

← 1 2 →