A MyD88-deficient mouse model reveals a role for Nramp1 in Campylobacter jejuni infection

被引:48
作者
Watson, Robert O. [1 ]
Novik, Veronica [1 ]
Hofreuter, Dirk [1 ]
Lara-Tejero, Maria [1 ]
Galan, Jorge E. [1 ]
机构
[1] Yale Univ, Sch Med, Sect Microbial Pathogenesis, New Haven, CT 06536 USA
关键词
TOLL-LIKE RECEPTORS; PROTEIN GLYCOSYLATION; IN-VITRO; GASTROINTESTINAL-TRACT; EPITHELIAL-CELLS; FLAGELLIN GENES; HOST-RESISTANCE; COLONIZATION; INVASION; IMMUNITY;
D O I
10.1128/IAI.01216-06
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Campylobacter jejuni is a major worldwide cause of enteric illnesses. Adult immunocompetent mice are not susceptible to C jejuni infection. However, we show here that mice deficient in the adaptor protein myeloid differentiation factor 88 (MyD88), which is required for signaling through most Toll-like receptors, can be stably colonized by C jejuni but not by isogenic derivatives carrying mutations in known virulence genes. We also found that Nramp1 deficiency increases the mouse susceptibility to C.jejuni infection when administered systemically. These results indicate that MyD88-deficient mice could be a useful model to study C. jejuni colonization and reveal a potential role for Nramp1 in the control of this bacterial pathogen.
引用
收藏
页码:1994 / 2003
页数:10
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