Genetics and pathogenesis of coeliac disease

被引：39

作者：

Heap, Graham A. ^{[1
]}

van Heel, David A. ^{[1
]}

机构：

[1] Queen Mary Univ London, Ctr Gastroenterol, Inst Cell & Mol Sci, Barts & London Sch Med & Dent, London E1 2AT, England

来源：

SEMINARS IN IMMUNOLOGY | 2009年 / 21卷 / 06期

基金：

英国惠康基金;

关键词：

Coeliac; Celiac; Genetics; Immunology; Immunogenetics; T-CELL EPITOPE; TISSUE TRANSGLUTAMINASE; GLIADIN PEPTIDES; CUTTING EDGE; INTERFERON-GAMMA; INTRAEPITHELIAL LYMPHOCYTES; CROSS-LINKING; A-GLIADIN; GLUTEN; RISK;

D O I：

10.1016/j.smim.2009.04.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Coeliac disease is a common complex disease caused by a dietary intolerance to wheat gluten. Susceptibility is determined by both environmental and genetic factors. Coeliac disease results from complex interactions between the innate immune system, an adaptive T and B cell response and the mucosal barrier where inflammation is ultimately manifested. Genetic variants within the HLA region are well established, while variants outside of the HLA region have recently been identified. These variants are beginning to enhance our understanding of the immunology of the condition. This review focuses on the immunological pathogenesis of coeliac disease with special reference to the influence of genetic susceptibility on disease development. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：346 / 354

页数：9

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