Intracellular trafficking of carbon nanotubes by confocal laser scanning microscopy

被引：60

作者：

Lacerda, Lara

Pastorin, Giorgia

Gathercole, David

Buddle, Joanna

Prato, Maurizio

Bianco, Alberto

Kostarelos, Kostas

机构：

[1] Univ London, Sch Pharm, Nanomed Lab, Ctr Drug Delivery Res, London WC1N 1AX, England

[2] Univ London, Sch Pharm, Nanomed Lab, Confocal Microscopy Unit, London WC1N 1AX, England

[3] CNRS, Inst Biol Mol & Cellulaire, Lab Immunol & Chim Therapeut, F-67084 Strasbourg, France

[4] UCL, Inst Child Hlth, London WC1N 1EH, England

[5] Univ Trieste, Dipartimento Sci Farmaceut, I-34127 Trieste, Italy

来源：

ADVANCED MATERIALS | 2007年 / 19卷 / 11期

关键词：

D O I：

10.1002/adma.200601412

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Intracellular trafficking of ammoniumn-functionalized single-walled carbon nanotubes reveals that after cell internalization the nanotubes translocate around the cell nucleus of human lung carcinoma cells (A549). The luminescent signal of the carbon nanotubes (no fluorescent labels) is used for 3D intracellular tracking (see figure). The presented methodology is expected to offer a widely usable tool that will further elucidate the intracellular transport mechanisms of carbon nanotubes.

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页码：1480 / +

页数：6

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