Adolescent risky decision-making: Neurocognitive development of reward and control regions

被引:342
作者
Van Leijenhorst, Linda [1 ,2 ]
Moor, Bregtje Gunther [1 ,2 ,3 ]
de Macks, Zdena A. Op [1 ]
Rombouts, Serge A. R. B. [1 ,2 ,4 ]
Westenberg, P. Michiel [1 ,2 ]
Crone, Eveline A. [1 ,2 ]
机构
[1] Leiden Univ, Inst Psychol, NL-2300 RB Leiden, Netherlands
[2] Leiden Inst Brain & Cognit, NL-2300 RC Leiden, Netherlands
[3] Univ Amsterdam, Dept Psychol, NL-1018 WB Amsterdam, Netherlands
[4] Leiden Univ, Med Ctr, Dept Radiol, NL-2300 RC Leiden, Netherlands
关键词
FUZZY-TRACE THEORY; ORBITOFRONTAL CORTEX; NUCLEUS-ACCUMBENS; BRAIN-DEVELOPMENT; NEURAL RESPONSES; AGE-DIFFERENCES; BEHAVIOR; PROBABILITY; SENSITIVITY; ACTIVATION;
D O I
10.1016/j.neuroimage.2010.02.038
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Recent models hypothesize that adolescents' risky behavior is the consequence of increased sensitivity to rewards in the ventral medial (VM) prefrontal cortex (PFC) and the ventral striatum (VS), paired with immature cognitive control abilities due to slow maturation of the dorsal anterior cingulate cortex (ACC) and lateral PFC. We tested this hypothesis with fMRI using a gambling task in which participants chose between Low-Risk gambles with a high probability of obtaining a small reward (1 Euro) and High-Risk gambles with a smaller probability of obtaining a higher reward (2, 4, 6, or 8 Euro). We examined neural responses during choice selection and outcome processing in participants from 4 age groups (pre-pubertal children, early adolescents, older adolescents and young adults). High-Risk choices increased with rewards for all ages, but risk-taking decreased with age for low reward gambles. The fMRI results confirmed that High-Risk choices were associated with activation in VMPFC, whereas Low-Risk choices were associated with activation in lateral PFC. Activation in dorsal ACC showed a linear decrease with age, whereas activation in VMPFC and VS showed an inverted U-shaped developmental pattern, with a peak in adolescence. In addition, behavioral differences in risk-taking propensity modulated brain activation in all age groups. These findings support the hypothesis that risky behavior in adolescence is associated with an imbalance caused by different developmental trajectories of reward and regulatory brain circuitry. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码:345 / 355
页数:11
相关论文
共 52 条
[1]  
Achenbach TM, 1991, INTEGRATIVE GUIDE 19
[2]   Trajectories of brain development: point of vulnerability or window of opportunity? [J].
Andersen, SL .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2003, 27 (1-2) :3-18
[3]   Incentive-elicited brain activation in adolescents: Similarities and differences from young adults [J].
Bjork, JM ;
Knutson, B ;
Fong, GW ;
Caggiano, DM ;
Bennett, SM ;
Hommer, DW .
JOURNAL OF NEUROSCIENCE, 2004, 24 (08) :1793-1802
[4]   The development of risk-taking: A multi-perspective review [J].
Boyer, Ty W. .
DEVELOPMENTAL REVIEW, 2006, 26 (03) :291-345
[5]   Functional imaging of neural responses to expectancy and experience of monetary gains and losses [J].
Breiter, HC ;
Aharon, I ;
Kahneman, D ;
Dale, A ;
Shizgal, P .
NEURON, 2001, 30 (02) :619-639
[6]  
Brett M., 2002, REG INTEREST ANAL US, V16, P497
[7]   Neurodevelopmental changes in working memory and cognitive control [J].
Bunge, Silvia A. ;
Wright, Samantha B. .
CURRENT OPINION IN NEUROBIOLOGY, 2007, 17 (02) :243-250
[8]  
Casey BJ, 2008, DEV REV, V28, P62, DOI [10.1016/j.dr.2007.08.003, 10.1196/annals.1440.010]
[9]   Structural and functional brain development and its relation to cognitive development [J].
Casey, BJ ;
Giedd, JN ;
Thomas, KM .
BIOLOGICAL PSYCHOLOGY, 2000, 54 (1-3) :241-257
[10]   Changes in cerebral functional organization during cognitive development [J].
Casey, BJ ;
Galvan, A ;
Hare, TA .
CURRENT OPINION IN NEUROBIOLOGY, 2005, 15 (02) :239-244