T-cell anti-apoptotic mechanisms in inflammatory myopathies

被引：23

作者：

Vattemi, G ^{[1
]}

Tonin, P ^{[1
]}

Filosto, M ^{[1
]}

Spagnolo, M ^{[1
]}

Rizzuto, N ^{[1
]}

Tomelleri, G ^{[1
]}

机构：

[1] Univ Verona, Dept Neurol Sci & Vis, I-37100 Verona, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 111卷 / 1-2期

关键词：

inflammatory myopathies; Fas/Fas ligand system; apoptosis; bcl-2 protein family; cyclin-dependent kinase inhibitors;

D O I：

10.1016/S0165-5728(00)00381-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies have shown an up-regulation of the Fas/Fas ligand system in inflammatory myopathies. In myositis, however, the major Fas-mediated cytotoxicity which activates caspases bypasses apoptosis. We therefore evaluated the expression of proteins promoting cell survival, such as bcl-2, bcl-x(1) and cyclin-dependent kinase inhibitors, on muscle biopsies from 14 patients with polymyositis, dermatomyositis, inclusion body myositis and HIV-associated myositis. Our data demonstrate that inflammatory cells are immunoreactive for bcl-x(1), p16 and p57, three apoptosis-preventing proteins. Hence, we assume that these proteins might protect T cells from apoptotic nuclear changes. Our results could explain the non-self-limiting nature of inflammatory myopathies. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：146 / 151

页数：6

共 31 条

[1] The Bcl-2 protein family: Arbiters of cell survival [J].