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A new pair of HLA-C alleles, Cw*12042 and Cw*1203, differing at the KIR-related dimorphism of codons 77-80

被引：9
作者：
Vilches, C
Bunce, M
van Dam, M
de Pablo, R
机构：
[1] Clin Puerta Hierro, Serv Inmunol, E-28035 Madrid, Spain
[2] Churchill Hosp, Oxford Transplant Ctr, Oxford OX3 7LJ, England
[3] St Marys Hosp, Tissue Typing Lab, London, England
来源：
TISSUE ANTIGENS | 1998年 / 51卷 / 01期
关键词：
Cw*12; haplotype; HLA-C; new allele; nucleotide sequence; PCR-SSP;
D O I：
10.1111/j.1399-0039.1998.tb02953.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A previously unknown HLA-C variant of the Cw*12 group was identified by PCR-SSP from genomic DNA of cell NDS-JD. Molecular cloning and nucleotide sequence analysis permitted the characterization of the complete coding region of this new allele, Cw*12042. The new variant differs from the recently reported Cw*12041 by two silent changes at exons 2 and 3, and from Cw*1203 by coding changes at codons 77 and 80. Cw*1203 (Ser Asn) and Cw*12042 (Asn-Lys) constitute the second known example of HLA-C alleles only differing at the KIR-related dimorphism of residues 77-80. The new allele is associated in cell NDS-JD with the haplotype HLA-A*2403, Cw*12042, B*51, DRB1*1502, DRB5*0102, DQB1*0601, possibly related from the evolutionary aspect to the ancestral haplotype A*2402, Cw*1202, B*5201, DRB1*1502, DRB5*0102, DQB1*0601.
引用
收藏
页码：101 / 105
页数：5
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