The secretory protein sec8 is required for paraxial mesoderm formation in the mouse

被引:64
作者
Friedrich, GA [1 ]
Hildebrand, JD [1 ]
Soriano, P [1 ]
机构
[1] Fred Hutchinson Canc Res Ctr, Div Basic Sci, Seattle, WA 98104 USA
基金
新加坡国家研究基金会;
关键词
D O I
10.1006/dbio.1997.8727
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The sec8 gene, isolated in a gene trap screen in embryonic stem cells, is required for paraxial mesoderm formation in the mouse. Homozygous sec8 mutant embryos initiate gastrulation but are unable to progress beyond the primitive streak stage and die shortly afterward. The genomic locus and cDNA of the sec8 gene have been cloned. An open reading frame in the cDNA encodes a 971-amino-acid leucine-rich protein, similar to rat rSec8. A description of the mutant phenotype and the cloning of the gene is presented here and the results are considered in light of the possibility that the Sec8 protein is involved in secretion. (C) 1997 Academic Press.
引用
收藏
页码:364 / 374
页数:11
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