A murine TSPY

被引：26

作者：

Vogel, T

Boettger-Tong, H

Nanda, I

Dechend, F

Agulnik, AI

Bishop, CE

Schmid, M

Schmidtke, JR ^{[1
]}

机构：

[1] Hannover Med Sch, Inst Human Genet, D-30623 Hannover, Germany

[2] Baylor Coll Med, Dept Obstet & Gynecol, Houston, TX 77030 USA

[3] Univ Wurzburg, Inst Human Genet, D-97074 Wurzburg, Germany

来源：

CHROMOSOME RESEARCH | 1998年 / 6卷 / 01期

基金：

美国国家卫生研究院;

关键词：

murine TSPY; Y chromosome;

D O I：

10.1023/A:1009214307764

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sequences homologous to human and bovine TSPY were isolated from M. musculus testicular cDNA, and a nearly full-length gene was polymerase chain reaction (PCR) amplified from mouse genomic DNA. This gene is apparently non-functional. Contrary to the situation encountered in species along the primate and artiodactyl lineages, in which TSPY is moderately repetitive, murine Tspy appears to be single copy. Murine Tspy is located on Yp, i.e. in the same syntenic group as in man. Sequence comparisons of murine, human and bovine TSPY exons suggest that TSPY became non-functional during rodent evolution.

引用

页码：35 / 40

页数：6

共 18 条

[1]

[Anonymous], 1993, Human gene mutation

[2] A HUMAN Y-CHROMOSOMAL DNA-SEQUENCE EXPRESSED IN TESTICULAR TISSUE [J].