Influence of the-675 4G/5G dimorphism of the plasminogen activator inhibitor 1 promoter on thrombotic risk in patients with factor V Leiden

被引：18

作者：

Visanji, JM ^{[1
]}

Seargent, J ^{[1
]}

Tahri, D ^{[1
]}

Croft, SA ^{[1
]}

Makris, M ^{[1
]}

Preston, FE ^{[1
]}

Peake, IR ^{[1
]}

Daly, ME ^{[1
]}

机构：

[1] Univ Sheffield, Royal Hallamshire Hosp, Fac Med, Div Mol & Genet Med, Sheffield S10 2JE, S Yorkshire, England

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2000年 / 110卷 / 01期

关键词：

PAI-1; 4G/5G; dimorphism; venous; thromboembolism;

D O I：

10.1046/j.1365-2141.2000.02152.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Elevated plasminogen activator inhibitor 1 (PAI-1) levels are associated with venous thromboembolism. although their significance is unclear. PAI-1 levels are influenced by a PAI-1 promoter dimorphism (4G/5G), the 4G allele being associated with increased PAI-1 activity We investigated whether the 4G allele influenced thrombotic risk by studying 99 symptomatic factor V (FV) Leiden heterozygotes and 99 healthy subjects. The 4G allele was more prevalent among cases than among healthy subjects (chi(2) = 8.00, P = 0.005) and the odds ratio (OR) for thrombosis associated with either heterozygosity or homozygosity for the 4G allele was 3.43 (P = 0.011). We conclude that carriership of the 4G allele was more prevalent in patients who already carried factor V Leiden than in control subjects without factor V Leiden.

引用

页码：135 / 138

页数：4

共 12 条

[1] HIGH PREVALENCE OF A MUTATION IN THE FACTOR-V GENE WITHIN THE UK POPULATION - RELATIONSHIP TO ACTIVATED PROTEIN-C RESISTANCE AND FAMILIAL THROMBOSIS
BEAUCHAMP, NJ
DALY, ME
HAMPTON, KK
COOPER, PC
PRESTON, FE
PEAKE, IR
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1994, 88 (01) : 219 - 222
[2] DAWSON P, 1993, ADV XRAY CONTRAST, V1, P2
[3] GENETIC-DETERMINANTS OF ARTERIAL THROMBOSIS
GREEN, F
HUMPHRIES, S
[J]. BAILLIERES CLINICAL HAEMATOLOGY, 1994, 7 (03): : 675 - 692
[4] Lane DA, 1996, THROMB HAEMOSTASIS, V76, P651
[5] Makris M, 1997, THROMB HAEMOSTASIS, V78, P1426
[6] Marinelli I, 1997, THROMB HAEMOSTASIS, V77, P440
[7] A common genetic variation in the 3'-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis
Poort, SR
Rosendaal, FR
Reitsma, PH
Bertina, RM
[J]. BLOOD, 1996, 88 (10) : 3698 - 3703
[8] Arterial and venous thrombosis is not associated with the 4G/5G polymorphism in the promoter of the plasminogen activator inhibitor gene in a large cohort of US men
Ridker, PM
Hennekens, CH
Lindpaintner, K
Stampfer, MJ
Miletich, JP
[J]. CIRCULATION, 1997, 95 (01) : 59 - 62
[9] 4G/5G polymorphism of PAI-1 gene promoter and fibrinolytic capacity in patients with deep vein thrombosis
Sartori, MT
Wiman, B
Vettore, S
Dazzi, F
Girolami, A
Patrassi, GM
[J]. THROMBOSIS AND HAEMOSTASIS, 1998, 80 (06) : 956 - 960
[10] Stegnar M, 1998, THROMB HAEMOSTASIS, V79, P975

← 1 2 →