Is the calcium-ion catalysis of biological reoxidation of reduced PQQ purely electrostatic?

被引：11

作者：

Schürer, G ^{[1
]}

Clark, T ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Inst Organ Chem, Comp Chem Centrum, D-91052 Erlangen, Germany

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 02期

关键词：

D O I：

10.1039/a707780g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Semiempirical (PM3) molecular orbital calculations on the mechanism of reoxidation of PQQ by triplet dioxygen suggest that the reaction can proceed purely by hydrogen-atom-transfer steps that are catalysed by the electrostatic effect of a coordinated calcium ion, rather than by an electron-transfer mechanism.

引用

页码：257 / 258

页数：2

共 28 条

[1] THE STRUCTURE AND FUNCTION OF METHANOL DEHYDROGENASE AND RELATED QUINOPROTEINS CONTAINING PYRROLO-QUINOLINE QUINONE [J].

ANTHONY, C ;

GHOSH, M ;

BLAKE, CCF .

BIOCHEMICAL JOURNAL, 1994, 304 :665-674

[2] THE ACTIVE-SITE OF METHANOL DEHYDROGENASE CONTAINS A DISULFIDE BRIDGE BETWEEN ADJACENT CYSTEINE RESIDUES [J].

BLAKE, CCF ;

GHOSH, M ;

HARLOS, K ;

AVEZOUX, A ;

ANTHONY, C .

NATURE STRUCTURAL BIOLOGY, 1994, 1 (02) :102-105

[3] MODEL AB-INITIO STUDIES ON METHANE OXIDATION AND ETHYLENE EPOXIDATION BY THE PEROXY RADICAL COMPLEXED TO THE LITHIUM CATION - ARE PEROXY RADICAL COMPLEXES ACTIVE INTERMEDIATES IN BIOLOGICAL OXIDATIONS [J].

CLARK, T ;

HOFMANN, H .

JOURNAL OF PHYSICAL CHEMISTRY, 1994, 98 (51) :13797-13803

[4] ODD-ELECTRON DELTA-BONDS [J].

CLARK, T .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (06) :1672-1678

[5] RADICAL-ADDITION TO ALKENE METAL CATION COMPLEXES [J].

CLARK, T .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1986, (24) :1774-1776

[6]

Clark T., 1990, ANGEW CHEM, V102, P697

[7]

CLARK T, 1995, TOP CURR CHEM, V177, P1

[8] THE CHEMISTRY OF A 1,5-DIBLOCKED FLAVIN .2. PROTON AND ELECTRON-TRANSFER STEPS IN THE REACTION OF DIHYDROFLAVINS WITH OXYGEN [J].

EBERLEIN, G ;

BRUICE, TC .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1983, 105 (22) :6685-6697

[9]

EBERLEIN G, 1982, J AM CHEM SOC, V194, P1449

[10] REVERSIBLE THERMAL INACTIVATION OF THE QUINOPROTEIN GLUCOSE-DEHYDROGENASE FROM ACINETOBACTER-CALCOACETICUS - CA-2+ IONS ARE NECESSARY FOR RE-ACTIVATION [J].

GEIGER, O ;

GORISCH, H .

BIOCHEMICAL JOURNAL, 1989, 261 (02) :415-421

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