A working model of CaM kinase II activity in hippocampal long-term potentiation and memory

被引：105

作者：

Fukunaga, K ^{[1
]}

Miyamoto, E ^{[1
]}

机构：

[1] Kumamoto Univ, Sch Med, Dept Pharmacol, Kumamoto 8600811, Japan

来源：

NEUROSCIENCE RESEARCH | 2000年 / 38卷 / 01期

关键词：

CaM kinase II; long-term potentiation; long-term depression; hippocampus; memory;

D O I：

10.1016/S0168-0102(00)00139-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recent advances in molecular genetics provide strong evidence for a relationship between hippocampal long-term potentiation (LTP) and hippocampus-dependent memory. The alpha-CaM kinase II knock-out mouse and transgenic mice expressing a mutant form of CaM kinase II clearly demonstrate that CaM kinase II plays a prominent role in hippocampal LTP and hippocampus-dependent memory. Furthermore, the observation that there is a diversity of silent as well as functional synapses has shed light on the molecular basis of learning and memory during development as well as in adult brain. Here sie present a working model of CaM kinase II activity as a memory molecule in hippocampal LTP and describe molecular targets of CaM kinase II involved in the establishment of functional synapses following LTP induction. (C) 2000 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.

引用

页码：3 / 17

页数：15

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