PPAR-γ:: therapeutic target for ischemic stroke

被引：144

作者：

Culman, Juraj ^{[1
]}

Zhao, Yi ^{[1
]}

Gohlke, Peter ^{[1
]}

Herdegen, Thomas ^{[1
]}

机构：

[1] Univ Hosp Schleswig Holstein, Inst Pharmacol, D-24105 Kiel, Germany

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2007年 / 28卷 / 05期

关键词：

D O I：

10.1016/j.tips.2007.03.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The peroxisome proliferator activated receptors (PPARs), which belong to the nuclear receptor superfamily, are key regulators of glucose and fat metabolism. The PPAR-gamma isoform is involved in the regulation of cellular glucose uptake, protection against atherosclerosis and control of immune reactions. In addition, the activation of PPAR-gamma effectively attenuates neurodegenerative and inflammatory processes in the brain. Here, we review a novel aspect of beneficial and clinically relevant PPAR-gamma actions: neuroprotection against ischemic injury mediated by intracerebral PPAR-gamma, which is expressed in neurons and microglia. Together with the recent observation that the PPAR-gamma ligand pioglitazone reduces the incidence of stroke in patients with type 2 diabetes, this review supports the concept that activators of PPAR-gamma are effective drugs against ischemic injury.

引用

页码：244 / 249

页数：6

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