The expression of vascular endothelial growth factor and transforming growth factor-beta associates with angiogenesis in epithelial ovarian cancer

被引：104

作者：

Nakanishi, Y ^{[1
]}

Kodama, J ^{[1
]}

Yoshinouchi, M ^{[1
]}

Tokumo, K ^{[1
]}

Kamimura, S ^{[1
]}

Okuda, H ^{[1
]}

Kudo, T ^{[1
]}

机构：

[1] OKAYAMA UNIV, SCH MED, DEPT OBSTET & GYNECOL, OKAYAMA 700, JAPAN

来源：

INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY | 1997年 / 16卷 / 03期

关键词：

epithelial ovarian cancer; angiogenesis; VEGF; TGF beta;

D O I：

10.1097/00004347-199707000-00011

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The object of this study was to clarify the association between microvessel density and clinicopathologic factors, as well as the association of angiogenic factors (vascular endothelial growth factor [VEGF] and transforming growth factor-beta [TGF-beta]) with tumor angiogenesis and patient survival in epithelial ovarian cancer. The expression of VEGF and TGF-beta was evaluated by immunohistochemical staining in 60 patients with epithelial ovarian cancer. The microvessel density, assessed by immunostaining for factor VIII-related antigen in the most neovascularized areas, varied depending on histological types but not an International Federation of Gynecology and Obstetrics stage. Patients with stage III carcinomas and positive TGF-beta had more extensive peritoneal dissemination and a worse outcome. The microvessel density of VEGF-rich and TGF-beta positive tumors was significantly higher than that of VEGF-poor and TGF-beta negative tumors. Angiogenesis appears to be an early event in epithelial ovarian cancer and may be induced differently in tumors of different histological types. The expression of VEGF and TGF-beta associates with the promotion of angiogenesis, and the expression of TGF-beta is a prognostic indicator in epithelial ovarian cancers.

引用

页码：256 / 262

页数：7

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