Innate immune sensing and its roots: the story of endotoxin

被引：1028

作者：

Beutler, B ^{[1
]}

Rietschel, ET

机构：

[1] Scripps Res Inst, La Jolla, CA 92037 USA

[2] Res Ctr Borstel, D-23845 Borstel, Germany

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri1004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

How does the host sense pathogens? Our present concepts grew directly from longstanding efforts to understand infectious disease: how microbes harm the host, what molecules are sensed and, ultimately, the nature of the receptors that the host uses. The discovery of the host sensors - the Toll-like receptors - was rooted in chemical, biological and genetic analyses that centred on a bacterial poison, termed endotoxin.

引用

页码：169 / 176

页数：8

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