Phospholamban domain I cytochrome b5 transmembrane sequence chimeras do not inhibit SERCA2a

被引：7

作者：

Kimura, Y

Asahi, M

Kurzydlowski, K

Tada, M

MacLennan, DH ^{[1
]}

机构：

[1] Univ Toronto, Charles H Best Inst, Banting & Best Dept Med Res, Toronto, ON M5G 1L6, Canada

[2] Osaka Univ, Sch Med, Dept Med & Pathophysiol, Suita, Osaka 5650871, Japan

来源：

FEBS LETTERS | 1998年 / 425卷 / 03期

关键词：

Ca2+-ATPase; phospholamban; cytochrome b(5); sarcoplasmic reticulum;

D O I：

10.1016/S0014-5793(98)00151-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of chimeras between the transmembrane domains of phospholamban (PLN) and cytochrome b(5) were coexpressed with the Ca2+-ATPase of cardiac sarcoplasmic reticulum (SERCA2a), The chimeric molecules were not inhibitory, in line with our view that inhibitory PLN/SERCA2a interactions occur in transmembrane sequences, while cytoplasmic interactions regulate the inhibitory interactions in a four-base circuit. (C) 1998 Federation of European Biochemical Societies.

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收藏

页码：509 / 512

页数：4

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