STRA6, a cell-surface receptor for retinol-binding protein: The plot thickens

被引：64

作者：

Blaner, William S. ^{[1
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Dept Med, New York, NY 10032 USA

来源：

CELL METABOLISM | 2007年 / 5卷 / 03期

关键词：

D O I：

10.1016/j.cmet.2007.02.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

How retinol (vitamin A) is taken up by cells has been an area of active research since the first report of a cell-surface receptor for retinol-binding protein (RBP) in the mid-1970s. Two recent reports, by Kawaguchi et al. (2007) and Pasutto et al. (2007), provide compelling data regarding the molecular identity and properties of a RBP receptor and open new research avenues for a better understanding of retinoid biology.

引用

页码：164 / 166

页数：3

共 11 条

[1]

Biesalski HK, 1999, AM J CLIN NUTR, V69, P931

[2] Developmental expression pattern of Stra6, a retinoic acid-responsive gene encoding a new type of membrane protein [J].

Bouillet, P ;

Sapin, V ;

Chazaud, C ;

Messaddeq, N ;

Decimo, D ;

Dolle, P ;

Chambon, P .

MECHANISMS OF DEVELOPMENT, 1997, 63 (02) :173-186

[3] The nuclear receptor superfamily:: A personal retrospect on the first two decades [J].

Chambon, P .

MOLECULAR ENDOCRINOLOGY, 2005, 19 (06) :1418-1428

[4] A membrane receptor for retinol binding protein mediates cellular uptake of vitamin A [J].

Kawaguchi, Riki ;

Yu, Jiamei ;

Honda, Jane ;

Hu, Jane ;

Whitelegge, Julian ;

Ping, Peipei ;

Wiita, Patrick ;

Bok, Dean ;

Sun, Hui .

SCIENCE, 2007, 315 (5813) :820-825

[5] Mutations in STRA6 cause a broad spectrum of malformations including anophthalmia, congenital heart defects, diaphragmatic hernia, alveolar capillary dysplasia, lung hypoplasia, and mental retardation [J].

Pasutto, Francesca ;

Sticht, Heinrich ;

Hammersen, Gerhard ;

Gillessen-Kaesbach, Gabriele ;

FitzPatrick, David R. ;

Nuernberg, Gudrun ;

Brasch, Frank ;

Schirmer-Zimmermann, Heidemarie ;

Tolmie, John L. ;

Chitayat, David ;

Houge, Gunnar ;

Fernandez-Martinez, Lorena ;

Keating, Sarah ;

Mortier, Geert ;

Hennekam, Raoul C. M. ;

von der Wense, Axel ;

Slavotinek, Anne ;

Meinecke, Peter ;

Bitoun, Pierre ;

Becker, Christian ;

Nuernberg, Peter ;

Reis, Andre ;

Rauch, Anita .

AMERICAN JOURNAL OF HUMAN GENETICS, 2007, 80 (03) :550-560

[6] Impaired retinal function and vitamin A availability in mice lacking retinol-binding protein [J].

Quadro, L ;

Blaner, WS ;

Salchow, DJ ;

Vogel, S ;

Piantedosi, R ;

Gouras, P ;

Freeman, S ;

Cosma, MP ;

Colantuoni, V ;

Gottesman, ME .

EMBO JOURNAL, 1999, 18 (17) :4633-4644

[7]

Sporn M.B., 1994, RETINOIDS BIOL CHEM

[8]

Szeto W, 2001, CANCER RES, V61, P4197

[9] REEXPRESSION OF RETINOIC ACID RECEPTOR (RAR)GAMMA OR OVEREXPRESSION OF RAR-ALPHA OR RAR-BETA IN RAR-GAMMA-NULL F9 CELLS REVEALS A PARTIAL FUNCTIONAL REDUNDANCY BETWEEN THE 3 RAR TYPES [J].

TANEJA, R ;

BOUILLET, P ;

BOYLAN, JF ;

GAUB, MP ;

ROY, B ;

GUDAS, LJ ;

CHAMBON, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (17) :7854-7858

[10]

Vogel S., 1999, HANDB EXP PHARM, V139, P31

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