Intestinal IgA synthesis: Regulation of front-line body defences

被引：362

作者：

Fagarasan, S

Honjo, T ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Med Chem, Sakyo Ku, Kyoto 6068501, Japan

[2] RIKEN, Res Ctr Allergy & Immunol, Tsurumi Ku, Yokohama, Kanagawa 2300045, Japan

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 01期

关键词：

D O I：

10.1038/nri982

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunoglobulin A is the most abundant immunoglobulin isotype in mucosal secretions. In this review, we summarize recent advances in our understanding of the sites, mechanisms and functions of intestinal IgA synthesis in mice. On the basis of these recent findings, we propose an updated model for the induction and regulation of IgA responses in the gut. In addition, we discuss new insights into the role of IgA in the maintenance of gut homeostasis and into the reciprocal interactions between gut B cells and the bacterial flora.

引用

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页码：63 / 72

页数：10

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