The death effector domain protein family: regulators of cellular homeostasis

被引:167
作者
Tibbetts, MD [1 ]
Zheng, LX [1 ]
Lenardo, MJ [1 ]
机构
[1] NIAID, Immunol Lab, Bethesda, MD 20892 USA
关键词
D O I
10.1038/ni0503-404
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The death effector domain (DED) occurs in proteins that regulate programmed cell death. Both pro- and anti-apoptotic proteins containing DEDs have been identified. For Fas and possibly other death receptors, homotypic DIED interactions connect the Fas-associated death domain (FADD) protein to caspase-8 and caspase-10 to mediate formation of the death-inducing signal complex. This complex can be inhibited by other DED-containing proteins. Accumulating evidence now suggests that DED-containing proteins have additional roles in controlling pathways of cellular activation and proliferation. Thus, the DED defines a family of proteins that may be pivotal to cellular homeostasis by establishing a 'cell renewal set point' that coregulates proliferation and apoptosis in parallel.
引用
收藏
页码:404 / 409
页数:6
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