Comparative proteomic expression profile in all-trans retinoic acid differentiated neuroblastoma cell line

被引：26

作者：

Cimmino, Flora ^{[1
]}

Spano, Daniela ^{[1
]}

Capasso, Mario ^{[1
]}

Zambrano, Nicola ^{[1
]}

Russo, Roberta ^{[1
]}

Zollo, Massimo ^{[1
]}

Iolascon, Achille ^{[1
]}

机构：

[1] Univ Naples Federico II, Dipartimento Biochim & Biotecnol Med, Ctr Ingn Genet CEINGE Biotecnol Avanzate, I-80145 Naples, Italy

来源：

JOURNAL OF PROTEOME RESEARCH | 2007年 / 6卷 / 07期

关键词：

neuroblastoma; all-trans-retinoic acid; 2D-DIGE; LAN-5 human neuroblastoma cell line;

D O I：

10.1021/pr060701g

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuroblastoma (NB) is an infant tumor which frequently differentiates into neurons. We used two-dimensional differential in-gel electrophoresis (2D-DIGE) to analyze the cytosolic and nuclear protein expression patterns of LAN-5 cells following neuronal differentiating agent all-trans-retinoic acid treatment. We identified several candidate proteins, from which G beta 2 and Prefoldin 3 may have a role on NB development. These results strength the use of proteomics to discover new putative protein targets in cancer.

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收藏

页码：2550 / 2564

页数：15

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