Sarcopenia-consequences, mechanisms; and potential therapies

Increasingly, the worldwide population is growing older. Sarcopenia occurs with age and is characterized by loss of muscle mass, strength and endurance. Mechanisms that underlie this process are beginning to be understood. These include age-related loss and atrophy of individual muscle fibers, decreased synthesis of muscle proteins, and reduced mitochondrial function. The role of decreased anabolic hormone production in causing these changes remains to be clearly defined. Anabolic hormone replacement is a potential strategy currently being investigated for treatment of sarcopenia. Combinations of aerobic, resistance, and stretching exercise programs have well established beneficial effects. Further understanding of the molecular processes involved in the aging of muscle both at the level of gene expression and protein modification will be important for discovering novel treatment strategies. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.