Sesquiterpenoids from Artemisia gilvescens and an anti-MRSA compound

被引：30

作者：

Kawazoe, K

Tsubouchi, Y

Abdullah, N

Takaishi, Y

Shibata, H

Higuti, T

Hori, H

Ogawa, M

机构：

[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan

[2] Univ Tokushima, Fac Engn, Tokushima 7708506, Japan

[3] Tokushima Prefectural Museum, Tokushima 7708070, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2003年 / 66卷 / 04期

关键词：

D O I：

10.1021/np020593m

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new secoguaianolide sesquiterpene (1) was isolated along with its three stereoisomers (2-4) from the nonmedicinal plant Artemisia gilvescens. The structure of 1 was elucidated to be (4S*,5S*)-dihydro-5-[(1R*,2S*)-2-hydroxy-2-methyl-5-oxo-3-cyclopenten-1-yl]-3-methylene-4-(3-oxobutyl)-2(3H)-furanone on the basis of 2D NMR and other spectroscopic evidence. Five known sesquiterpenoids were also isolated from this plant, and one of them (5) showed activity against methicillin-resistant Staphylococcus aureus (MRSA).

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页码：538 / 539

页数：2

相关论文

共 14 条

[1] Taraxacin, a new guaianolide from Taraxacum wallichii [J].

Ahmad, VU ;

Yasmeen, S ;

Ali, Z ;

Khan, MA ;

Choudhary, MI ;

Akhtar, F ;

Miana, GA ;

Zahid, M .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (07) :1010-1011

[2] A PHOTO ARTIFACT FROM LINDERAZULENE [J].

ALPERTUNGA, B ;

IMRE, S ;

COWE, HJ ;

COX, PJ ;

THOMSON, RH .

TETRAHEDRON LETTERS, 1983, 24 (41) :4461-4462

[3] REVISED STRUCTURES FOR GUAIANOLIDE ALPHA-METHYLENEBUTYRO-LACTONES FROM FEVERFEW [J].

BEGLEY, MJ ;

HEWLETT, MJ ;

KNIGHT, DW .

PHYTOCHEMISTRY, 1989, 28 (03) :940-943

[4] NATURALLY-OCCURRING TERPENE DERIVATIVES .454. SESQUITERPENE LACTONES AND OTHER CONSTITUENTS FROM TANACETUM-PARTHENIUM [J].

BOHLMANN, F ;

ZDERO, C .

PHYTOCHEMISTRY, 1982, 21 (10) :2543-2549

[5] Sesquiterpene lactones from feverfew, Tanacetum parthenium: Isolation, structural revision, activity against human blood platelet function and implications for migraine therapy [J].

Hewlett, MJ ;

Begley, MJ ;

Groenewegen, WA ;

Heptinstall, S ;

Knight, DW ;

May, J ;

Salan, U ;

Toplis, D .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1996, (16) :1979-1986

[6] SECO-GUAIANOLIDES AND OTHER CONSTITUENTS FROM ARTEMISIA SPECIES [J].

HUNECK, S ;

ZDERO, C ;

BOHLMANN, F .

PHYTOCHEMISTRY, 1986, 25 (04) :883-889

[7]

*JAP SOC CHEM, 1981, CHEMOTHERAPY, V29, P76

[8] Sesquiterpene lactones, inhibitors of farnesyl protein transferase, isolated from the flower of Artemisia sylvatica [J].

Lee, SH ;

Kang, HM ;

Song, HC ;

Lee, H ;

Lee, UC ;

Son, KH ;

Kim, SH ;

Kwon, BM .

TETRAHEDRON, 2000, 56 (27) :4711-4715

[9] A GUAIANOLIDE PIGMENT FROM A DEEP-SEA GORGONIAN [J].

LI, MKW ;

SCHEUER, PJ .

TETRAHEDRON LETTERS, 1984, 25 (20) :2109-2110

[10] SESQUITERPENE LACTONES FROM IRANIAN ARTEMISIA SPECIES [J].

MARCO, JA ;

SANZCERVERA, JF ;

MANGLANO, E ;

SANCENON, F ;

RUSTAIYAN, A ;

KARDAR, M .

PHYTOCHEMISTRY, 1993, 34 (06) :1561-1564