Separation and assay methods for melatonin and its precursors

被引：39

作者：

Harumi, T ^{[1
]}

Matsushima, S ^{[1
]}

机构：

[1] Asahikawa Med Coll, Dept Anat, Asahikawa, Hokkaido 0788510, Japan

来源：

JOURNAL OF CHROMATOGRAPHY B | 2000年 / 747卷 / 1-2期

关键词：

reviews; melatonin; indoleamines;

D O I：

10.1016/S0378-4347(00)00064-5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Melatonin is an indoleamine hormone that is synthesized from tryptophan via 5-hydroxytryptophan, serotonin and N-acetylserotonin in the vertebrate pineal gland. Many chromatographic and non-chromatographic techniques have been developed and improved for the determination and measurement of melatonin and its related indoleamines. At present, gas chromatography with mass spectrometry and reversed-phase high-performance liquid chromatography with fluorescence or electrochemical detection are widely used for indoleamine determinations in the pineal gland. This review will deal with methods for the separation and determination of the melatonin and its related indoleamines. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：95 / 110

页数：16

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