Molecular genetics of intraductal papillary-mucinous neoplasms of the pancreas

被引：10

作者：

Furukawa, Toru ^{[1
]}

机构：

[1] Tokyo Womens Med Univ, Int Res & Educ Inst Integrated Med Sci, Shinjuku Ku, Tokyo 1628666, Japan

来源：

JOURNAL OF HEPATO-BILIARY-PANCREATIC SURGERY | 2007年 / 14卷 / 03期

关键词：

IPMN; PanIN; pancreatic cancer; SMAD4; DUSP6;

D O I：

10.1007/s00534-006-1167-4

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Intraductal papillary-mucinous neoplasms of the pancreas show characteristic clinicopathological and molecular pathobiological features which are distinct from those of conventional ductal adenocarcinomas. Alterations of KRAS, AKT/PKB, CDKN2A, TP53, SMAD4, STK11/LKB1, and DUSP6, and other molecular alterations, including global expression studies as well as their clinical implications, are discussed.

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页码：233 / 237

页数：5

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