Unbalanced chromosomal rearrangements in a metastasizing salivary gland tumor with benign histology

被引：14

作者：

Jin, YS ^{[1
]}

Jin, C

Arheden, K

Larsson, O

Bauer, HFC

Mandahl, N

Mertens, F

机构：

[1] Univ Lund Hosp, Dept Clin Genet, S-22185 Lund, Sweden

[2] Karolinska Hosp, Dept Pathol, S-10401 Stockholm, Sweden

[3] Karolinska Hosp, Dept Orthoped, S-10401 Stockholm, Sweden

来源：

CANCER GENETICS AND CYTOGENETICS | 1998年 / 102卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(97)00301-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Benign metastasizing pleomorphic adenoma (BMPA) is a rare tumor of the salivary glands. Despite benign histopathologic features, it can metastasize and is sometimes lethal. No chromosomal data have been reported for this tumor type We have by chromosome banding and fluorescence in situ hybridization analysis examined the short-term cultures of three skeletal metastases from a BMPA and identified two related hypodiploid clones: 44,XX,dic(3;22)(p11;q13) or der(3)t(3;22)(p11;q?) add (22)(q?),der(9;21)(q10;q10),der(13)t(1;13)(q11;p13)/45,XX,-3,der(9;21)(q10;q10),der(13)t(1;13)(q11; p13),?der(22)t(3;22)(q22;q13), + mar. The karyotypic features of this BMPA thus differ from the characteristic cytogenetic findings in pleomorphic adenomas and carcinomas ex pleomorphic adenoma. (C) Elsevier Science Inc., 1998.

引用

页码：59 / 64

页数：6

共 17 条

[1] CYTOGENETIC SUBTYPING OF 220 SALIVARY-GLAND PLEOMORPHIC ADENOMAS - CORRELATION TO OCCURRENCE, HISTOLOGICAL SUBTYPE, AND INVITRO CELLULAR BEHAVIOR [J].