Control systems and decision making for antibody production

被引：316

作者：

Goodnow, Christopher C. ^{[1
]}

Vinuesa, Carola G. ^{[1
]}

Randall, Katrina L. ^{[1
,2
]}

Mackay, Fabienne ^{[3
]}

Brink, Robert ^{[4
,5
]}

机构：

[1] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 2601, Australia

[2] Canberra Hosp, Dept Immunol, Garran, ACT, Australia

[3] Monash Univ, Dept Immunol, Fac Med Nursing & Hlth Sci, Melbourne, Vic 3004, Australia

[4] Garvan Inst Med Res, Darlinghurst, NSW, Australia

[5] Univ New S Wales, St Vincents Clin Sch, Sydney, NSW, Australia

来源：

NATURE IMMUNOLOGY | 2010年 / 11卷 / 08期

基金：

美国国家卫生研究院; 澳大利亚研究理事会; 英国医学研究理事会; 英国惠康基金;

关键词：

B-CELL RECEPTOR; PRIMARY IMMUNE-RESPONSE; HELPER T-CELLS; GERMINAL-CENTER; PLASMA-CELLS; ANTIGEN RECEPTOR; PHOSPHATIDYLINOSITOL; 3-KINASE; AFFINITY MATURATION; DENDRITIC CELLS; SELF-TOLERANCE;

D O I：

10.1038/ni.1900

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This paper synthesizes recent progress toward understanding the integrated control systems and fail-safes that guide the quality and quantity of antibody produced by B cells. We focus on four key decisions: (1) the choice between proliferation or death in perifollicular B cells in the first 3 days after antigen encounter; (2) differentiation of proliferating perifollicular B cells into extrafollicular plasma cells or germinal center B cells; (3) positive selection of B cell antigen receptor (BCR) affinity for foreign antigen versus negative selection of BCR affinity for self antigen in germinal center B cells; and (4) survival versus death of antibody-secreting plasma cells. Understanding the engineering of these control systems represents a challenging future step for treating disorders of antibody production in autoimmunity, allergy and immunodeficiency.

引用

页码：681 / 688

页数：8

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