Distinct Biological Network Properties between the Targets of Natural Products and Disease Genes

被引：56

作者：

Dancik, Vlado ^{[1
]}

Seiler, Kathleen Petri ^{[1
]}

Young, Damian W. ^{[1
]}

Schreiber, Stuart L. ^{[1
]}

Clemons, Paul A. ^{[1
]}

机构：

[1] Broad Inst Harvard & MIT, Cambridge, MA 02143 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 27期

关键词：

DRUG DISCOVERY; ORGANISMS;

D O I：

10.1021/ja102798t

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We show that natural products target proteins with a high number of protein-protein functional interactions (high biological network connectivity) and that these protein targets have higher network connectivity than disease genes. This feature may facilitate disruption of essential biological pathways, resulting in competitor death. This result also suggests that additional sources of small molecules will be required to discover drugs targeting the root causes of human disease in the future.

引用

收藏

页码：9259 / 9261

页数：3

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