A case of Guillain-Barre syndrome following a family outbreak of Campylobacter jejuni enteritis

被引：30

作者：

Ang, CW

van Doorn, PA

Endtz, HP

Merkies, ISJ

Jacobs, BC

de Klerk, MA

van Koningsveld, R

van der Meche, FGA

机构：

[1] Erasmus Univ, Dept Neurol, NL-3000 DR Rotterdam, Netherlands

[2] Erasmus Univ, Dept Immunol, NL-3000 DR Rotterdam, Netherlands

[3] Erasmus Univ, Dept Med Microbiol & Infect Dis, NL-3015 GD Rotterdam, Netherlands

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 111卷 / 1-2期

关键词：

anti-glycolipid antibodies; HLA-system; lipopolysaccharide; molecular mimicry;

D O I：

10.1016/S0165-5728(00)00369-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe an outbreak of Campylobacter jejuni enteritis involving three family members of whom one developed Guillain-Barre syndrome (GBS). The patients' serum reacted strongly with several gangliosides and with the lipopolysaccharide (LPS) fractions from the C. jejuni strains isolated from his family members. Only low titer anti-ganglioside antibodies were found in his siblings. HLA-typing did not indicate a locus associated with auto-antibody production. Comparing the immune response in GBS patients and C. jejuni enteritis patients can be of great value in determining the additional factors that lead to post-Campylobacter GBS. Ganglioside mimicry alone is necessary but not sufficient for the induction of anti-ganglioside antibodies. Other susceptibility factors are required to induce an anti-neural immune response. (C) 2000 Elsevier Science BN. All rights reserved.

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页码：229 / 233

页数：5

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