Autoimmune heart failure: new understandings of pathogenesis

被引：34

作者：

Eriksson, U

Penninger, JM

机构：

[1] Univ Basel Hosp, Dept Internal Med, CH-4031 Basel, Switzerland

[2] Univ Basel Hosp, Dept Res, Div Expt Crit Care Med, CH-4031 Basel, Switzerland

[3] Austrian Acad Sci, IMBA, Inst Mol Biotechnol, A-1030 Vienna, Austria

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2005年 / 37卷 / 01期

关键词：

autoimmunity; myocarditis; cardiomyopathy; heart failure; innate immunity;

D O I：

10.1016/j.biocel.2004.06.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Besides genetic susceptibility and infections with cardiotropic viruses, autoimmune responses against heart tissue play a major role in the pathogenesis of dilated cardiomopathy, the most common cause of heart failure in young patients. Recent findings suggest that the combination of tissue damage resulting in release of self-antigens, together with non-specific activation of the innate immune system triggers various responses that are crucial for the development of heart-specific autoimmunity. Understanding these mechanisms is critical for the design and development of novel treatment strategies against devastating heart diseases in the future. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：27 / 32

页数：6

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