Activity-dependent neuroprotective protein: From gene to drug candidate

被引：60

作者：

Gozes, Ilana ^{[1
]}

机构：

[1] Tel Aviv Univ, Sackler Fac Med, Adams Super Ctr Brain Studies, Lab Mol Neuroendocrinol,Lily & Avraham Gildor Cha, IL-69978 Tel Aviv, Israel

[2] Tel Aviv Univ, Sackler Fac Med, Levi Edersheim Gitter fMRI Inst, Dept Human Mol Genet & Biochem, IL-69978 Tel Aviv, Israel

[3] Allon Therapeut Inc, Vancouver, BC V6B 2S2, Canada

来源：

PHARMACOLOGY & THERAPEUTICS | 2007年 / 114卷 / 02期

基金：

以色列科学基金会;

关键词：

vasoactive intestinal peptide; activity-dependent neuroprotective protein; neuroprotection; glial cells;

D O I：

10.1016/j.pharmthera.2007.01.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Activity-dependent neuroprotective protein (ADNP) is essential for brain formation. The gene encoding ADNP is highly conserved and abundantly expressed in the brain. ADNP contains a homeobox profile and a peptide motif providing neuroprotection against a variety of cytotoxic insults. ADNP mRNA and protein expression responds to brain injury and oscillates as a function of the estrus cycle. The plastic nature of ADNP expression is correlated with brain protection and an association between neuroendocrine regulation and neuroprotection is put forth with ADNP as a focal point. Further understanding of neuroprotective molecules should pave the path to better diagnostics and therapies. In this respect, structure-activity studies have identified a short 8 amino acid peptide in ADNP/NAPVSIPQ (NAP) that provides potent neuroprotection. NAP is currently in clinical development for neuroprotection. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：146 / 154

页数：9

共 68 条

[1] Intranasal administration of NAP, a neuroprotective peptide, decreases anxiety-like behavior in aging mice in the elevated plus maze [J].