Pathogenesis of non-alcoholic fatty liver disease in children and adolescence: From "two hit theory" to "multiple hit model"

被引：541

作者：

Fang, Yan-Lan ^{[1
]}

Chen, Hong ^{[2
]}

Wang, Chun-Lin ^{[1
]}

Liang, Li ^{[1
]}

机构：

[1] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Dept Pediat, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China

[2] Zhejiang Univ, Coll Med, Hangzhou 310003, Zhejiang, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2018年 / 24卷 / 27期

关键词：

Non-alcoholic steatohepatitis; Children; Adolescents; Pathogenesis; Nonalcoholic fatty liver disease; DENSITY-LIPOPROTEIN RECEPTOR; NF-KAPPA-B; HEPATIC STEATOSIS; INSULIN-RESISTANCE; OBESE CHILDREN; CONFERS SUSCEPTIBILITY; CHOLESTEROL-METABOLISM; GENE POLYMORPHISMS; WIDE ASSOCIATION; EXPERT COMMITTEE;

D O I：

10.3748/wjg.v24.i27.2974

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Nonalcoholic fatty liver disease (NAFLD) has become the dominant form of chronic liver disease in children and adolescents with the increasing prevalence of obesity worldwide. NAFLD represents a wide spectrum of conditions, ranging from fatty liver - which generally follows a benign, non-progressive clinical course - to non-alcoholic steatohepatitis, a subset of NAFLD that may progress to cirrhosis and end-stage liver disease or liver carcinoma. The underlying pathophysiological mechanism of "pediatric" NAFLD remains unclear, although it is strongly associated with obesity and insulin resistance. In this review we provide a general overview on the current understanding of NAFLD in children and adolescents, which underpins practice, enabling early diagnosis and appropriate therapeutic intervention for this life-threatening liver disease.

引用

页码：2974 / 2983

页数：10

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