Genetic determinants of the pre- and post-azathioprine therapy thiopurine methyltransferase activity phenotype

被引：18

作者：

Arenas, M ^{[1
]}

Duley, JA ^{[1
]}

Ansari, A ^{[1
]}

Shobowale-Bakre, EA ^{[1
]}

Fairbanks, L ^{[1
]}

Soon, SY ^{[1
]}

Sanderson, J ^{[1
]}

Marinaki, AM ^{[1
]}

机构：

[1] Guys & St Thomas Hosp, Dept Gastroenterol, London SE1 9RT, England

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2004年 / 23卷 / 8-9期

关键词：

VNTR; Variable Number Tandem Repeats; AZA; azathioprine; 6MP; 6mercaptopurine and TPMT; thiopurine methyltransferase;

D O I：

10.1081/NCN-200027643

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Thiopurine drug therapy has been reported to lead to a variable increase in red cell TPMT activity that may alter effective dose and therapeutic outcome. The aim of this study was to correlate Variable Number Tandem Repeat (VNTR) in the promoter region of the TPMT gene with induction of red cell TPMT activity in patients treated with azathioprine (AZA). In 58 patients, TPMT activity measured at 3 months was not significantly induced on average above pre-therapy levels. Individual patients showed variation in TPMT activity pre- and post-AZA therapy, however changes in TPMT activity were not predicted by VNTR configuration. In conclusion, TPMT promoter VNTRs are unlikely to play a significant role in changes in TPMT activity in response to AZA therapy.

引用

页码：1403 / 1405

页数：3

共 3 条

[1] Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease [J].

Ansari, A ;

Hassan, C ;

Duley, J ;

Marinaki, A ;

Shobowale-Bakre, EM ;

Seed, P ;

Meenan, J ;

Yim, A ;

Sanderson, J .

ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2002, 16 (10) :1743-1750

[2] TPMT in the treatment of Crohn's disease with azathioprine [J].

Lennard, L .

GUT, 2002, 51 (02) :143-146

[3] Genetic determinants of the thiopurine methyltransferase intermediate activity phenotype in British Asians and Caucasians [J].

Marinaki, AM ;

Arenas, M ;

Khan, ZH ;

Lewis, CM ;

Shobowale-Bakre, EM ;

Escuredo, E ;

Fairbanks, LD ;

Mayberry, JF ;

Wicks, AC ;

Ansari, A ;

Sanderson, J ;

Duley, JA .

PHARMACOGENETICS, 2003, 13 (02) :97-105

← 1 →