An approach to use an unusual adenosine transporter to selectively deliver polyamine analogues to trypanosomes

被引：42

作者：

Tye, CK

Kasinathan, G

Barrett, MP

Brun, R

Doyle, VE

Fairlamb, AH

Weaver, R

Gilbert, IH

机构：

[1] Univ Wales Coll Cardiff, Welsh Sch Pharm, Cardiff CF1 3XF, S Glam, Wales

[2] Univ Glasgow, Inst Biomed & Life Sci, Div Infect & Immun, Glasgow G12 8QQ, Lanark, Scotland

[3] Univ Dundee, Dept Biochem, Dundee DD1 4HN, Scotland

[4] Swiss Trop Inst, CH-4002 Basel, Switzerland

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0960-894X(98)00095-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In this paper we describe an approach to selectively deliver compounds to trypanosomes using an adenosine transporter which is unique to the trypanosome. Various polyamine analogues have been attached to known substrates of this adenosine transporter. The compounds prepared interact specifically with the adenosine transporter, some with a similar efficiency to berenil, a known substrate. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：811 / 816

页数：6

共 14 条

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