Association of FOBT-assessed faecal Hb content with colonic lesions detected in the Florence screening programme

被引：74

作者：

Ciatto, S. ^{[1
]}

Martinelli, F. ^{[1
]}

Castiglione, G. ^{[1
]}

Mantellini, P. ^{[1
]}

Rubeca, T. ^{[1
]}

Grazzini, G. ^{[1
]}

Bonanomi, A. G. ^{[1
]}

Confortini, M. ^{[1
]}

Zappa, M. ^{[1
]}

机构：

[1] Ctr Studio & Prevenz Oncol, I-50131 Florence, Italy

来源：

BRITISH JOURNAL OF CANCER | 2007年 / 96卷 / 02期

关键词：

colorectal cancer; faecal occult blood testing; FOBT; screening;

D O I：

10.1038/sj.bjc.6603534

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We assessed the correlation between quantitative results of immunological faecal occult blood testing (I-FOBT) and colonic lesions (191 colorectal cancers, 890 adenomas) detected at colonoscopy in 2597 FOBT + (cutoff 100 ng ml(-1) Hb) subjects. At univariate analysis, a higher average faecal Hb content was significantly associated with male gender (P = 0.003), age (P = 0.02), and colonoscopy findings (P = 0.000). Among adenomas, higher faecal Hb content was significantly associated with size (P = 0.0000), presence of severe dysplasia (P = 0.0001), presence of villous component (P = 0.0002), and location in the left colon (P = 0.003). At multivariate analysis adjusting for potential confounders, age (P = 0.03), size (P = 0.0000), and location in the left colon (P = 0.0005) were confirmed as having an independent association with higher faecal Hb content. Immunological FOBT is confirmed to be a specific screening test to detect cancer and adenoma, with a low positivity rate (3.7%) and a high positive predictive value (41.5%). Faecal Hb content is significantly higher for those lesions (cancer and high-risk adenomas) screening is aimed at detecting.

引用

页码：218 / 221

页数：4

共 19 条

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