Renal effects of water-soluble polyarylsulfonated C60 in rats with an acute toxicity study

被引：13

作者：

Chen, HHC ^{[1
]}

Yu, C

Ueng, TH

Liang, CT

Chen, BJ

Hong, CC

Chiang, LY

机构：

[1] Natl Sci Council, Natl Lab Anim Breeding, Nankang, Taiwan

[2] Natl Sci Council, Res Ctr, Nankang, Taiwan

[3] Natl Taiwan Univ, Dept Anim Sci, Taipei 10764, Taiwan

[4] Natl Taiwan Univ, Inst Toxicol, Taipei 10764, Taiwan

[5] Natl Taiwan Univ, Ctr Condensed Matter Sci, Taipei 10764, Taiwan

来源：

FULLERENE SCIENCE AND TECHNOLOGY | 1997年 / 5卷 / 07期

关键词：

D O I：

10.1080/15363839708013327

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Acute toxicity study of water soluble C(60) was conducted in young female rats with one dose intraperitoneal injection of C(60) ((CH(2))(4)SO(3)Na)(4-6). The preliminary results indicated its LD(50) value as approximately 600 mg/kg. The compound induced a unique phagolysosome-overload nephropathy that may serve as a biological marker in toxicity screening test for a series of synthesized water-soluble fullerenes.

引用

页码：1387 / 1396

页数：10

共 14 条

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