Association of the brain-derived neurotrophic factor Val66Met polymorphism with reduced hippocampal volumes in major depression

被引:287
作者
Frodl, Thomas
Schuele, Cornelius
Schmitt, Gisela
Born, Christine
Baghai, Thomas
Zill, Peter
Bottlender, Ronald
Rupprecht, Rainer
Bondy, Brigitta
Reiser, Maximilian
Moeller, Hans-Juergen
Meisenzahl, Eva M.
机构
[1] Univ Munich, Dept Psychiat & Psychotherapy, D-80336 Munich, Germany
[2] Univ Munich, Dept Radiol, D-80336 Munich, Germany
[3] Newham Ctr Mental Hlth, E London & City Mental Hlth NHS Trust, Dept Psychiat, London, England
关键词
FACTOR GENETIC-POLYMORPHISM; FACTOR BDNF GENE; 1ST EPISODE; CODING VARIANT; MESSENGER-RNA; HUMAN-MEMORY; AMYGDALA; SCHIZOPHRENIA; DISORDER; MRI;
D O I
10.1001/archpsyc.64.4.410
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Context: Brain-derived neurotrophic factor (BDNF) modulates hippocampal plasticity, which is believed to be altered in patients with major depression. Objective: To examine the effect of the BDNF Val66Met polymorphism on hippocampal and amygdala volumes in patients with major depression and in healthy control subjects. Design: Cross-sectional comparison between patients and controls. Setting: Inpatients with major depression from the Department of Psychiatry and Psychotherapy and healthy controls from the community were recruited. Participants: The study population of 120 subjects included 60 patients with major depression and 60 healthy controls. Main Outcome Measures: Using a combined strategy, hippocampal and amygdala volumes were estimated on high-resolution magnetic resonance images, and genotyping was performed for the BDNF Val66Met polymorphism. Results: Patients had significantly smaller hippocampal volumes compared with controls (P = .02). Significantly smaller hippocampal volumes were observed for patients and for controls carrying the Met-BDNF allele compared with subjects homozygous for the Val-BDNF allele (P= .006). With respect to amygdala volumes, no significant differences between patients and controls and no significant main effects for the BDNF Val66Met polymorphism were observed. Conclusions: These genotype-related alterations suggest that Met-BDNF allele carriers might be at risk to develop smaller hippocampal volumes and may be susceptible to major depression. This study supports findings from animal studies that the hippocampus is involved in brain development and plasticity.
引用
收藏
页码:410 / 416
页数:7
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