Binding of hydrogen sulfide by bismuth does not prevent dextran sulfate-induced colitis in rats

被引:19
作者
Furne, JK [1 ]
Suarez, FL [1 ]
Ewing, SL [1 ]
Springfield, J [1 ]
Levitt, MD [1 ]
机构
[1] MPLS VAMC, Res Serv, Minneapolis, MN 55417 USA
关键词
hydrogen sulfide; bismuth; colitis; rats;
D O I
10.1023/A:1005580709390
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Several lines of evidence suggest that ulcerative colitis could be caused by excessive bacterial production of H2S in the colon. A rodent model of colitis involves the feeding of nonabsorbable, carbohydrate-bound sulfate in the form of dextran sulfate or carrageenan. The observation that metronidazole blocks the development of this colitis suggested that the injurious agent could be a sulfur-containing compound (such as H2S) that is released during the bacterial metabolism of the nonabsorbed sulfate. We tested this possibility by feeding rats dextran sulfate, with or without bismuth subsalicylate, a compound that avidly binds H2S. Bismuth subsalicylate reduced the fecal release of H2S in dextran sulfate-treated rats to values well below that of controls. Nevertheless, all the animals developed colitis. We conclude that excessive H2S production does not play a role in the dextran sulfate model of colitis.
引用
收藏
页码:1439 / 1443
页数:5
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