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Insulin and the blood-brain barrier

被引：243
作者：
Woods, SC
Seeley, RJ
Baskin, DG
Schwartz, MW
机构：
[1] Univ Cincinnati, Dept Psychiat, Cincinnati, OH 45267 USA
[2] Univ Washington, Dept Med, Seattle, WA 98108 USA
[3] Univ Washington, Dept Biol Struct, Seattle, WA 98108 USA
[4] VA Putget Sound Hlth Care Syst, Seattle, WA 98108 USA
[5] Harborview Med Ctr, Seattle, WA USA
来源：
CURRENT PHARMACEUTICAL DESIGN | 2003年 / 9卷 / 10期
关键词：
D O I：
10.2174/1381612033455323
中图分类号：
R9 [药学];
学科分类号：
1007 [药学];
摘要：
Although several possible mechanisms exist by which the pancreatic hormone, insulin, could enter the brain from the blood, most evidence suggests that the majority of it enters primarily by a receptor-mediated transport process. Many factors influence the rate of entry, including fasting and refeeding and several pathological conditions. Within the brain insulin acts on specific receptors to influence a number of behaviors, and especially caloric homeostasis and cognition.
引用
收藏
页码：795 / 800
页数：6
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