Recombinant HIV-1 Pr55gag virus-like particles:: potent stimulators of innate and acquired immune responses

被引：112

作者：

Deml, L

Speth, C

Dierich, MP

Wolf, H

Wagner, R

机构：

[1] Univ Regensburg, Inst Med Microbiol, D-93053 Regensburg, Germany

[2] Univ Innsbruck, Inst Hyg & Social Med, A-6020 Innsbruck, Austria

来源：

MOLECULAR IMMUNOLOGY | 2005年 / 42卷 / 02期

关键词：

HIV; gag; virus-like particles; innate immunity; adaptive immunity; vaccine;

D O I：

10.1016/j.molimm.2004.06.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several previous reports have clearly demonstrated the strong effectiveness of human immunodeficiency virus (HIV) Gag polyprotein-based virus-like particles (VLP) to stimulate humoral and cellular immune responses in complete absence of additional adjuvants. Yet, the mechanisms underlying the strong immunogenicity of these particulate antigens are still not very clear. However, current reports strongly indicate that these VLP act as "danger signals" to trigger the innate immune system and possess potent adjuvant activity to enhance the immunogenicity of per se only weakly immunogenic peptides and proteins. Here, we review the current understanding of how various particle-associated substances and other impurities may contribute to the observed immune-activating properties of these complex immunogens. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：259 / 277

页数：19

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