Endothelin (ET)-1 induced mucosal damage in the rat small intestine:: Role of ET1 receptors

被引:31
作者
Massberg, S
Boros, M
Leiderer, R
Baranyi, L
Okada, H
Messmer, K
机构
[1] Univ Munich, Klinikum Grosshadern, Inst Surg Res, D-81366 Munich, Germany
[2] Nagoya City Univ, Dept Mol Biol, Nagoya, Aichi 466, Japan
来源
SHOCK | 1998年 / 9卷 / 03期
关键词
D O I
10.1097/00024382-199803000-00004
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
The role of endothelin (ET)-1 as a mediator of small intestinal mucosal perfusion failure and tissue damage was investigated in the rat using intravital fluorescence videomicroscopy. The effects of intravenous infusion of ET-1 (3 nmol/kg) on functional capillary density, mucosal thickness, and the degree of mucosal damage were evaluated. Administration of ET-1 caused pronounced mucosal injury with a significant reduction of mucosal thickness compared with vehicle-treated control animals. Concomitantly, villous functional capillary density was markedly reduced 30 and 90 min after the infusion of ET-1, ETA receptor blockade by pretreatment with BQ 610 or with the navel ETA receptor antagonist ETR-P1/FL peptide prevented ET-1 induced capillary perfusion failure and mucosal damage. In contrast, the ETB receptor antagonist IRL 1038 was not effective. These results indicate that, acting via the ETA receptor, elevated levels of circulating ET-1 under Various pathophysiological conditions, such as septic or hemorrhagic shock, might impair nutritive perfusion of the intestinal mucosa and contribute to tissue injury.
引用
收藏
页码:177 / 183
页数:7
相关论文
共 27 条
  • [1] THE ANTISENSE HOMOLOGY BOX - A NEW MOTIF WITHIN PROTEINS THAT ENCODES BIOLOGICALLY-ACTIVE PEPTIDES
    BARANYI, L
    CAMPBELL, W
    OHSHIMA, K
    FUJIMOTO, S
    BOROS, M
    OKADA, H
    [J]. NATURE MEDICINE, 1995, 1 (09) : 894 - 901
  • [2] ENDOTHELIN-1 DOES NOT AFFECT HUMAN PLATELET-AGGREGATION IN WHOLE-BLOOD AND PLATELET RICH PLASMA
    BATTISTINI, B
    FILEP, JG
    HERMAN, F
    SIROIS, P
    [J]. THROMBOSIS RESEARCH, 1990, 60 (01) : 105 - 108
  • [3] BELMONTE J, 1993, BRIT J PHARMACOL, V108, P73
  • [4] ISCHEMIC TIME-DEPENDENT MICROVASCULAR CHANGES AND REPERFUSION INJURY IN THE RAT SMALL-INTESTINE
    BOROS, M
    TAKAICHI, S
    HATANAKA, K
    [J]. JOURNAL OF SURGICAL RESEARCH, 1995, 59 (02) : 311 - 320
  • [5] PLASMA ENDOTHELIN LEVEL CHANGES DURING HEMORRHAGIC-SHOCK
    CHANG, H
    WU, GJ
    WANG, SM
    HUNG, CR
    [J]. JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 1993, 35 (06) : 825 - 833
  • [6] CHIU CJ, 1970, ARCH SURG-CHICAGO, V101, P478
  • [7] EFFECTS OF ENDOTHELIN-1 ON VASCULAR-PERMEABILITY IN THE CONSCIOUS RAT - INTERACTIONS WITH PLATELET-ACTIVATING-FACTOR
    FILEP, JG
    SIROIS, MG
    ROUSSEAU, A
    FOURNIER, A
    SIROIS, P
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1991, 104 (04) : 797 - 804
  • [8] TERMINATION OF ENDOTHELIN SIGNALING - ROLE OF NITRIC-OXIDE
    GOLIGORSKY, MS
    TSUKAHARA, H
    MAGAZINE, H
    ANDERSEN, TT
    MALIK, AB
    BAHOU, WF
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 1994, 158 (03) : 485 - 494
  • [9] ENDOTHELIN-1 EVOKED AN INCREASE AND OSCILLATIONS IN CYTOSOLIC CALCIUM-CONCENTRATION IN ADHERENT SINGLE HUMAN PLATELETS AND INCREASED GMP-140 (P-SELECTIN) IN PLATELET SUSPENSION
    HALIM, A
    KANAYAMA, N
    ELMARADNY, E
    MAEHARA, K
    HIRANO, M
    KOBAYASHI, T
    TERAO, T
    [J]. THROMBOSIS RESEARCH, 1995, 80 (02) : 105 - 112
  • [10] BINDING-SITES FOR ENDOTHELIN-1 IN RAT-TISSUES - AN AUTORADIOGRAPHIC STUDY
    KOSEKI, C
    IMAI, M
    HIRATA, Y
    YANAGISAWA, M
    MASAKI, T
    [J]. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 1989, 13 : S153 - S154