Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series:: a structure-activity evaluation study

被引：42

作者：

Ferreira, ICFR

Calhelha, RC

Estevinho, LM

Queiroz, MJRP

机构：

[1] Escola Super Agraria, Inst Politecn Braganca, P-5301854 Braganca, Portugal

[2] Univ Minho, Dept Quim, P-4710057 Braga, Portugal

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 23期

关键词：

diarylamines; antimicrobial activity; SAR; benzothiophenes;

D O I：

10.1016/j.bmcl.2004.09.038

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Gram positive (Bacillus cereus, B. subtilis), Gram negative (Pseudomonas aeruginosa, Escherichia coli) bacteria, and Candida albicans as a representative of fungi were used for screening the in vitro antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series bearing different substituents, synthesized by us using the palladium-catalyzed C-N coupling methodology. The minimal inhibitory concentration (MIC) and structure-activity relationships (SARs) were evaluated. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：5831 / 5833

页数：3

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