Transcription start regions in the human genome are favored targets for MLV integration

被引：1016

作者：

Wu, XL

Li, Y

Crise, B

Burgess, SM ^{[1
]}

机构：

[1] NHGRI, Genome Technol Branch, NIH, Bethesda, MD 20892 USA

[2] Sci Applicat Int Corp, Frederick, MD 21702 USA

来源：

SCIENCE | 2003年 / 300卷 / 5626期

关键词：

D O I：

10.1126/science.1083413

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Factors contributing to retroviral integration have been intractable because past studies have not precisely located genomic sites of proviruses in sufficient numbers for significant analysis. In this study, 903 murine leukemia virus (MLV) and 379 human immunodeficiency virus-1 (HIV-1) integrations in the human genome were mapped. The data showed that MLV preferred integration near the start of transcriptional units ( either upstream or downstream) whereas HIV-1 preferred integration anywhere in the transcriptional unit but not upstream of the transcriptional start. Defining different integration site preferences for retroviruses will have important rami. cations for gene therapy and may aid in our understanding of the factors directing the integration process.

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页码：1749 / 1751

页数：3

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